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CGH Services

Comparative Genomic Hybridization with Agilent's Oligonucleotide CGH Arrays

The development of cancer is associated with gains and losses of DNA sequences throughout the genome. Array-based comparative genomic hybridization (aCGH) measures copy number variations at multiple loci simultaneously, providing an important tool for studying cancer and for developing diagnostic and therapeutic targets.

Our results demonstrate that Agilent oligonucleotide arrays designed for CGH provide a robust and precise platform for detecting chromosomal alterations throughout a genome with high sensitivity using full complexity genomic samples

Features

High-resolution tiling capability: Take advantage of ~4 million CGH probes (spaced at 400bp on average) to tile selected genomic regions at your desired resolution for refined mapping of genomic alterations.

Optimized probe design for CGH applications: Have complete confidence in our 60-mer oligonucleotide probes designed using Agilent’s powerful design algorithms and robust validation processes (based on NCBI genome build 35).

Customizable content: Design a single or a set of fully-customized microarrays tailored to your specific research needs with predesigned probes that span exonic, intronic, and intergenic regions of the genome.

Nanogram sample input : Only 100 ng of total genomic DNA per sample is required, conserving your precious, limited, and hard-to-procure clinical samples.

Total genomic DNA with NO complexity reduction: Eliminate potential biases introduced by the process and maximize the biological utility of your sample with a single, simplified sample preparation.

Integrated genomic research: Perform both CGH and gene expression analysis techniques on one technology platform.

Multiple array formats (ex. 1x44K, 1x22K, and 2x11K) printed using Agilent's SurePrint technology

Agilent's Human Genome CGH Microarray 44A is a high-resolution, high performance 60-mer oligonucleotide-based microarray that contains over 40,000 probes sourced from the NCBI genome (Build 34; July, 2003). Coupled with Agilent's CGH Analytics software, this microarray enables genome-wide survey and molecular profiling of genomic aberrations (i.e. copy number changes) on a single chip. This product is intended for use in research only.

Agilent's Mouse Genome CGH Microarray 44A is the only commercially-available product for genome-wide survey and molecular profiling of genomic aberrations (i.e. copy number changes) in mouse on a single chip. This high-resolution, high performance 60-mer oligonucleotide-based microarray contains ~43,000 probes sourced from the NCBI genome Build 33


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